Phase II study of temozolomide and topotecan (TOTEM) in children with relapsed or refractory extracranial and central nervous system tumors including medulloblastoma with post hoc Bayesian analysis: A European ITCC study

Author:

Le Teuff Gwénaël12ORCID,Castaneda‐Heredia Alicia3,Dufour Christelle3ORCID,Jaspan Timothy4,Calmon Raphael5,Devos Annick6,McHugh Kieran7,Leblond Pierre8,Frappaz Didier9,Aerts Isabelle10ORCID,Zwaan Christian M.6ORCID,Ducassou Stéphane11ORCID,Chastagner Pascal12,Verschuur Arnauld13,Corradini Nadège14,Casanova Michela15,Rubie Hervé16,Riccardi Riccardo17,Le Deley Marie‐Cecile12,Vassal Gilles18,Geoerger Birgit319ORCID,

Affiliation:

1. Université Paris‐Saclay, Univ Paris‐Sud, UVSQ, CESP, INSERM Villejuif France

2. Gustave Roussy Cancer CenterUniversité Paris‐SaclayBiostatistics and Epidemiology Unit Villejuif France

3. Gustave Roussy Cancer CenterDepartment of Pediatric and Adolescent Oncology Villejuif France

4. University Hospital Nottingham Nottingham United Kingdom

5. Necker Enfants Malades Paris France

6. Erasmus MC/Sophia Children's Hospital Rotterdam Rotterdam The Netherlands

7. Great Ormond Street Hospital for Children London United Kingdom

8. Centre Oscar‐LambretDepartment of Pediatric Oncology Lille France

9. Institut d'Hématologie et d'Oncologie pédiatrique Lyon France

10. Institut CurieSIREDO Oncology CenterPSL Research University Paris France

11. Centre Hospitalier Pellegrin Hôpital des Enfants Bordeaux France

12. Hôpital Brabois Enfants Nancy France

13. Hôpital de la Timone AP‐HM Marseille France

14. Centre Hospitalier UniversitaireDepartment of Pediatric and Adolescent Oncology Nantes France

15. Fondazione IRCCS Istituto Nazionale Tumori Milano Italy

16. Hôpital des Enfants Toulouse France

17. Universita Cattolica Gemelli Roma Italy

18. Gustave Roussy Cancer CenterClinical Research DirectionUniversité Paris‐SaclayUniv Paris‐Sud Villejuif France

19. Université Paris‐SaclayUniv Paris‐Sud CNRS UMR8203 Villejuif France

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

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