Blinded sample size re-estimation for recurrent event data with time trends

Author:

Schneider S.1,Schmidli H.2,Friede T.1

Affiliation:

1. Department of Medical Statistics; University Medical Center Göttingen; Göttingen Germany

2. Statistical Methodology; Novartis Pharma AG; Basel Switzerland

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference34 articles.

1. The role of internal pilot studies in increasing the efficacy of clinical trials;Wittes;Statistics in Medicine,1990

2. ICH harmonised tripartite guideline E9: statistical principles for clinical trials;ICH;Statistics in Medicine,1999

3. Committee for Medicinal Products for Human Use (CHMP). Reflection paper on methodological issues in confirmatory clinical trials planned with an adaptive design. CHMP/EWP/2459/02 2007 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003616.pdf

4. Food and Drug Administration (FDA). Guidancefor industry - Adaptive design clinical trials for drugs and biologics. Draft guidance 2010 http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm201790.pdf

5. Two-stage sample size reestimation based on a nuisance parameter: a review;Proschan;Journal of Biopharmaceutical Statistics,2005

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