The Leiodolide B Puzzle

Author:

Larivée Alexandre1,Unger John B.1,Thomas Mikaël1,Wirtz Conny1,Dubost Christophe1,Handa Shinya1,Fürstner Alois1

Affiliation:

1. Max‐Planck‐Institut für Kohlenforschung, 45470 Mülheim/Ruhr (Germany), Fax: (+49) 208‐306‐2994

Publisher

Wiley

Subject

General Medicine

Reference60 articles.

1. Cytotoxic Macrolides from a New Species of the Deep-Water Marine Sponge Leiodermatium

2. Cytotoxic Macrolides from a New Species of the Deep-Water Marine Sponge Leiodermatium.

3. The original publication contains two inconsistent spellings “leiodelide” and “leiodolide”. We use the “olide” nomenclature to denote the macrolide character of these metabolites.

4. Degradation studies proved theS configuration at C28 in leiodolide A. Interestingly however small amounts of the 28R epimer were also detected suggesting that the biosynthetic formation of this remote center may not be stereospecific.

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