Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)‐Catalyzed C−H Activation/Carbene Insertion/Lossen Rearrangement Sequence-Reference-Cited by-同舟云学术

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Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)‐Catalyzed C−H Activation/Carbene Insertion/Lossen Rearrangement Sequence

Published:2019-08-07 Issue:38 Volume:131 Page:13469-13473
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Ma Biao¹,Wu Peng²,Wang Xing¹,Wang Zhengyu¹,Lin Hai‐Xia²,Dai Hui‐Xiong¹³^ORCID

Affiliation:

1. Chinese Academy of Sciences Key Laboratory of Receptor ResearchShanghai Institute of Materia Medica Shanghai 201203 China

2. Department of ChemistryInnovative Drug Research CenterShanghai University 99 Shangda Road Shanghai 200444 China

3. Stake Key Laboratory of Natural and Biomimetic DrugsPeking University Beijing 100191 China

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Program of Shanghai Academic Research Leader

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201906589

Reference89 articles.

1. For selected examples see:

2. Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT 7 receptor ligands

3. Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

4. Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide

5. Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

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1. [4 + 2] Cyclization or Lossen Rearrangement: Rhodium-Catalyzed Divergent Synthesis of Carboline Derivatives with Anticancer Activity;Organic Letters;2024-05-14

2. Transition‐Metal‐Catalyzed Synthesis of Spiro Compounds through Activation and Cleavage of C−H Bonds;Asian Journal of Organic Chemistry;2022-11-22

3. Catalyst- and Additive-Free C(sp³)–H Functionalization of (Thio)barbituric Acids via C-5 Dehydrogenative Aza-Coupling Under Ambient Conditions;ACS Omega;2022-08-17

4. Rhodium(III)‐Catalyzed Asymmetric [4+1] and [5+1] Annulation of Arenes and 1,3‐Enynes: A Distinct Mechanism of Allyl Formation and Allyl Functionalization;Angewandte Chemie International Edition;2020-10-07

5. Rhodium(III)‐Catalyzed Asymmetric [4+1] and [5+1] Annulation of Arenes and 1,3‐Enynes: A Distinct Mechanism of Allyl Formation and Allyl Functionalization;Angewandte Chemie;2020-10-07

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