Discovery of a PCAF Bromodomain Chemical Probe-Reference-Cited by-同舟云学术

Discovery of a PCAF Bromodomain Chemical Probe

Published:2016-12-14 Issue:3 Volume:129 Page:845-849
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Moustakim Moses¹²^ORCID,Clark Peter G. K.³,Trulli Laura⁴,Fuentes de Arriba Angel L.²,Ehebauer Matthias T.⁵,Chaikuad Apirat⁶,Murphy Emma J.⁵,Mendez‐Johnson Jacqui⁷,Daniels Danette⁷,Hou Chun‐Feng D.⁸,Lin Yu‐Hui⁸,Walker John R.⁸,Hui Raymond⁸,Yang Hongbing⁹,Dorrell Lucy⁹,Rogers Catherine M.¹,Monteiro Octovia P.¹,Fedorov Oleg¹,Huber Kilian V. M.¹,Knapp Stefan⁶,Heer Jag¹⁰,Dixon Darren J.²,Brennan Paul E.¹⁵^ORCID

Affiliation:

1. Structural Genomics Consortium & Target Discovery Institute University of Oxford NDM Research Building Roosevelt Drive Oxford OX3 7DQ and OX3 7FZ UK

2. Department of Chemistry Chemistry Research Laboratory University of Oxford Mansfield Road Oxford OX1 3TA UK

3. Department of Chemistry Simon Fraser University Burnaby V5A 1S6 Canada

4. Dipartimento di Chimica Università degli Studi di Roma “La Sapienza” Piazzale Aldo Moro 5 00185 Roma Italy

5. ARUK Oxford Drug Discovery Institute University of Oxford Oxford OX3 7FZ UK

6. Johann Wolfgang Goethe-University Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences 60438 Frankfurt am Main Germany

7. Promega Corporation 2800 Woods Hollow Road Madison WI 153611 USA

8. Structural Genomics Consortium MaRS South Tower, Suite 732 101 College Street Toronto Ontario M5G 1LZ Canada

9. Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre University of Oxford Oxford OX3 7FZ UK

10. UCB Pharma Ltd Slough SL1 3WE UK

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201610816

Reference55 articles.

2. The promise and peril of chemical probes

3. Epigenetic protein families: a new frontier for drug discovery

4. Targeting bromodomains: epigenetic readers of lysine acetylation

5. http://www.thesgc.org/chemical-probes.

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent contributions of pyridazine as a privileged scaffold of anticancer agents in medicinal chemistry: An updated review;Bioorganic & Medicinal Chemistry;2024-09

2. Binding mechanism of anacardic acid, carnosol and garcinol with PCAF: A comprehensive study using molecular docking and molecular dynamics simulations and binding free energy analysis;Journal of Cellular Biochemistry;2023-03-26

3. From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity;Bioorganic & Medicinal Chemistry;2021-07

4. 1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity;New Journal of Chemistry;2021

5. Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies;Bioorganic Chemistry;2020-07