Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor‐Induced Combinatorial Pairing of Stig Cyclases-Reference-Cited by-同舟云学术

Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor‐Induced Combinatorial Pairing of Stig Cyclases

Published:2020-03-19 Issue:21 Volume:132 Page:8243-8249
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Li Shasha¹^ORCID,Newmister Sean A.²,Lowell Andrew N.²³,Zi Jiachen⁴,Chappell Callie R.⁵,Yu Fengan²,Hohlman Robert M.¹,Orjala Jimmy⁴,Williams Robert M.⁶⁷,Sherman David H.⁸^ORCID

Affiliation:

1. Life Sciences InstituteDepartment of Medicinal ChemistryThe University of Michigan USA

2. Life Science InstituteThe University of Michigan USA

3. Department of ChemistryVirginia Tech Blacksburg VA 24061 USA

4. Department of Pharmaceutical SciencesCollege of PharmacyUniversity of Illinois at Chicago Chicago IL 60612 USA

5. Department of Molecular, Cellular & Developmental BiologyThe University of Michigan USA

6. Department of ChemistryColorado State University Fort Collins CO 80523 USA

7. University of Colorado Cancer Center Aurora CO 80045 USA

8. Life Sciences InstituteDepartments of Medicinal Chemistry, Chemistry, Microbiology & ImmunologyThe University of Michigan 210 Washtenaw Avenue Ann Arbor MI 48109-2216n USA

Funder

Foundation for the National Institutes of Health

National Science Foundation of Sri Lanka

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201913686

Reference33 articles.

2. Hapalindoles: new alkaloids from the blue-green alga Hapalosiphon fontinalis

3. Hapalindole H Induces Apoptosis as an Inhibitor of NF-ĸB and Affects the Intrinsic Mitochondrial Pathway in PC-3 Androgen-insensitive Prostate Cancer Cells

4. Indole Alkaloids from Fischerella Inhibit Vertebrate Development in the Zebrafish (Danio rerio) Embryo Model