Malignant melanoma in a 12‐year‐old boy 17 months after completing hepatoblastoma treatment

Author:

Kanezawa Koji1,Yagasaki Hiroshi1ORCID,Arakawa Ayumu2,Hoshi Reina3,Uehara Shuichiro3ORCID,Morioka Ichiro1

Affiliation:

1. Pediatrics Nihon University Itabashi Hospital Tokyo Japan

2. Department of Pediatric Oncology National Cancer Center Hospital Tokyo Japan

3. Pediatric Surgery Nihon University Itabashi Hospital Tokyo Japan

Abstract

AbstractBackgroundMelanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.CaseWe report a case of a 12‐year‐old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not respond to immune checkpoint inhibitor therapy and died 6 weeks after being diagnosed with melanoma. Whole‐exome sequencing to examine 103 genes associated with cancer predisposition did not identify any germ‐line variants.ConclusionThis case study provides a unique example of melanoma in a childhood cancer survivor following hepatoblastoma treatment but does not identify any candidate variant to link hepatoblastoma and melanoma.

Publisher

Wiley

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