Organic Anion Transporting Polypeptide-Mediated Transport of, and Inhibition by, Asunaprevir, an Inhibitor of Hepatitis C Virus NS3 Protease

Author:

Eley T1,Han Y-H1,Huang S-P1,He B1,Li W1,Bedford W1,Stonier M1,Gardiner D1,Sims K1,Rodrigues AD2,Bertz RJ1

Affiliation:

1. Bristol-Myers Squibb; Research and Development; Princeton New Jersey USA

2. Pfizer; Research and Development; Groton Connecticut USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference26 articles.

1. Preclinical profile and characterization of the hepatitis C virus NS3 protease inhibitor asunaprevir (BMS-650032);McPhee;Antimicrob. Agents Chemother.,2012

2. The effect of hepatic impairment on the pharmacokinetics of asunaprevir, an HCV NS3 protease inhibitor;Eley;Antivir. Ther.,2014

3. Single and multiple ascending dose studies of the NS3 protease inhibitor asunaprevir in subjects with or without chronic hepatitis C;Pasquinelli;Antimicrob. Agents Chemother.,2012

4. Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options;Suzuki;J. Hepatol.,2013

5. Asunaprevir (ASV; BMS-650032), an NS3 protease inhibitor, in combination with peginterferon and ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C infection;Bronowicki;J. Hepatol.,2012

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