N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

Author:

Karuppagounder Saravanan S.12,Alin Lauren12,Chen Yingxin12,Brand David12,Bourassa Megan W.12,Dietrich Kristen3,Wilkinson Cassandra M.4,Nadeau Colby A.4,Kumar Amit12,Perry Steve5,Pinto John T.6,Darley-Usmar Victor7,Sanchez Stephanie8,Milne Ginger L.8,Pratico Domenico9,Holman Theodore R.5,Carmichael S. Thomas10,Coppola Giovanni11,Colbourne Frederick34,Ratan Rajiv R.12

Affiliation:

1. Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute; White Plains NY

2. Brain and Mind Research Institute and Department of Neurology; Weill Cornell Medicine; New York NY

3. Neuroscience and Mental Health Institute; Edmonton Alberta Canada

4. Department of Psychology; University of Alberta; Edmonton Alberta Canada

5. Department of Chemistry and Biochemistry; University of California at Santa Cruz; Santa Cruz CA

6. Department of Biochemistry and Molecular Biology; New York Medical College; Valhalla NY

7. Department of Pathology; University of Alabama at Birmingham; Birmingham AL

8. Department of Clinical Pharmacology; Vanderbilt University; Nashville TN

9. Alzheimer's Center at Temple University, Lewis Katz School of Medicine; Philadelphia PA

10. Department of Neurology; David Geffen School of Medicine at UCLA; Los Angeles CA

11. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience, David Geffen School of Medicine; University of California; Los Angeles, Los Angeles CA

Funder

Heart and Stroke Foundation of Canada

National Institutes of Health

Publisher

Wiley

Subject

Clinical Neurology,Neurology

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