Antibiotic-eluting orthopedic device to prevent early implant associated infections: Efficacy, biocompatibility and biodistribution studies in an ovine model

Author:

Gimeno Marina1,Pinczowski Pedro1,Mendoza Gracia2ORCID,Asín Javier1ORCID,Vázquez Francisco J.13ORCID,Vispe Eugenio4ORCID,García-Álvarez Felícito5ORCID,Pérez Marta6,Santamaría Jesús27,Arruebo Manuel27ORCID,Luján Lluís1ORCID

Affiliation:

1. Department of Animal Pathology; University of Zaragoza; Zaragoza Spain

2. Department of Chemical Engineering, Aragon Institute of Nanoscience (INA); University of Zaragoza; Zaragoza Spain

3. Veterinary Hospital, University of Zaragoza; Zaragoza Spain

4. Laboratory of Chromatography and Spectroscopy; Institute of Chemical Synthesis and Homogeneous Catalysis (ISQCH), University of Zaragoza-CSIC; Zaragoza Spain

5. Department of Orthopaedic Surgery and Traumatology, Hospital "Lozano Blesa”, Zaragoza Spain and Instituto de Investigaciones Sanitarias de Aragon (ISS Aragon); Zaragoza Spain

6. Department of Anatomy, Embryology and Genetics; University of Zaragoza; Zaragoza Spain

7. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine; CIBER-BBN; Madrid Spain

Publisher

Wiley

Subject

Biomedical Engineering,Biomaterials

Reference34 articles.

1. Internal fixation for fresh fractures and for non-union;Muller;Proc R Soc Med,1963

2. Total hip and total knee replacement (1);Harris;N Engl J Med,1990

3. Infection burden for hip and knee arthroplasty in the United States;Kurtz;J Arthroplast,2008

4. Prevalence of knee and hip osteoarthritis and the appropriateness of joint replacement in an older population;Quintana;Arch Intern Med,2008

5. Trends in the treatment of orthopaedic prosthetic infections;Bernard;J Antimicrob Chemother,2004

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