Propolis suppresses atopic dermatitis through targeting the MKK4 pathway

Author:

Cho Ye‐Ryeong1,Han Eui Jeong2,Heo Eun1,Jayasinghe Arachchige Maheshika Kumari2,Won Jihyun3,Lee Soohwan4,Kim Taegun1ORCID,Kim Sung‐Kuk5,Lim Seokwon4,Woo Soon Ok5,Han Gyoonhee1,Kang Wonku3,Ahn Ginnae2,Byun Sanguine16ORCID

Affiliation:

1. Department of Biotechnology Yonsei University Seoul Republic of Korea

2. Department of Food Technology and Nutrition Chonnam National University Yeosu Republic of Korea

3. College of Pharmacy Chung‐Ang University Seoul Republic of Korea

4. Department of Food Science and Biotechnology Gachon University Seongnam Republic of Korea

5. Department of Agrobiology, Division of Apiculture National Institute of Agricultural Sciences Wanju Republic of Korea

6. POSTECH Biotech Center Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea

Abstract

AbstractPropolis is a natural resinous substance made by bees through mixing various plant sources. Propolis has been widely recognized as a functional food due to its diverse range of beneficial bioactivities. However, the therapeutic effects of consuming propolis against atopic dermatitis (AD) remain largely unknown. The current study aimed to investigate the potential efficacy of propolis against AD and explore the active compound as well as the direct molecular target. In HaCaT keratinocytes, propolis inhibited TNF‐α‐induced interleukin (IL)‐6 and IL‐8 secretion. It also led to a reduction in chemokines such as monocyte chemoattractant protein‐1 (MCP‐1) and macrophage‐derived chemokine (MDC), while restoring the levels of barrier proteins, filaggrin and involucrin. Propolis exhibited similar effects in AD‐like human skin, leading to the suppression of AD markers and the restoration of barrier proteins. In DNCB‐induced mice, oral administration of propolis attenuated AD symptoms, improved barrier function, and reduced scratching frequency and transepidermal water loss (TEWL). In addition, propolis reversed the mRNA levels of AD‐related markers in mouse dorsal skin. These effects were attributed to caffeic acid phenethyl ester (CAPE), the active compound identified by comparing major components of propolis. Mechanistic studies revealed that CAPE as well as propolis could directly and selectively target MKK4. Collectively, these findings demonstrate that propolis may be used as a functional food agent for the treatment of AD.

Funder

National Research Foundation of Korea

Rural Development Administration

Publisher

Wiley

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