Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

Author:

Patrignoni Lorenza1ORCID,Hurtier Annabelle2,Orlacchio Rosa1,Joushomme Alexandre2,Poulletier de Gannes Florence2,Lévêque Philippe3,Arnaud‐Cormos Delia3,Revzani Hamid Reza4,Mahfouf Walid4,Garenne André2,Percherancier Yann2,Lagroye Isabelle1

Affiliation:

1. Paris Sciences et Lettres Research University‐École Pratique des Hautes Études (EPHE) IMS laboratory ‐ SANE team Paris France

2. Univ. Bordeaux, CNRS IMS laboratory / UMR 5218, SANE Team Talence France

3. Univ. Limoges, CNRS XLIM / UMR 7252, RF‐ELITE team Limoges France

4. Univ. Bordeaux, Inserm BRIC / UMR 1312, TRIO2 team Bordeaux France

Abstract

AbstractWhether human cells are impacted by environmental electromagnetic fields (EMF) is still a matter of debate. With the deployment of the fifth generation (5G) of mobile communication technologies, the carrier frequency is increasing and the human skin becomes the main biological target. Here, we evaluated the impact of 5G‐modulated 3.5 GHz radiofrequency (RF) EMF on mitochondrial stress in human fibroblasts and keratinocytes that were exposed for 24 h at specific absorption rate of 0.25, 1, and 4 W/kg. We assessed cell viability, mitochondrial reactive oxygen species (ROS) production, and membrane polarization. Knowing that human skin is the main target of environmental ultraviolet (UV), using the same read‐out, we investigated whether subsequent exposure to 5G signal could alter the capacity of UV‐B to damage skin cells. We found a statistically significant reduction in mitochondrial ROS concentration in fibroblasts exposed to 5G signal at 1 W/kg. On the contrary, the RF exposure slightly but statistically significantly enhanced the effects of UV‐B radiation specifically in keratinocytes at 0.25 and 1 W/kg. No effect was found on mitochondrial membrane potential or apoptosis in any cell types or exposure conditions suggesting that the type and amplitude of the observed effects are very punctual.

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging,Physiology,General Medicine,Biophysics

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3