Robust dual‐angle T1 measurement in magnetization transfer spectroscopy by time‐optimal control

Author:

Graf Christina12ORCID,Stollberger Rudolf13,Rund Armin4,Schweiger Martina356,Diwoky Clemens5

Affiliation:

1. Institute of Biomedical Imaging Graz University of Technology Graz Austria

2. Department of Pediatrics University of British Columbia Vancouver, BC Canada

3. BioTechMed‐Graz Graz Austria

4. Institute for Mathematics and Scientific Computing Karl‐Franzens University Graz Graz Austria

5. Institute of Molecular Biosciences Karl‐Franzens University Graz Graz Austria

6. Field of Excellence BioHealthKarl‐Franzens University Graz Graz Austria

Abstract

SummaryMagnetization transfer spectroscopy relies heavily on the robust determination of relaxation times of nuclei participating in metabolic exchange. Challenges arise due to the use of surface RF coils for transmission (high variation) and the broad resonance band of most X nuclei. These challenges are particularly pronounced when fast mapping methods, such as the dual‐angle method, are employed. Consequently, in this work, we develop resonance offset and robust excitation RF pulses for 31P magnetization transfer spectroscopy at 7T through ensemble‐based time‐optimal control. In our approach, we introduce a cost functional for designing robust pulses, incorporating the full Bloch equations as constraints, which are solved using symmetric operator splitting techniques. The optimal control design of the RF pulses developed demonstrates improved accuracy, desired phase properties, and reduced RF power when applied to dual‐angle mapping, thereby improving the precision of exchange‐rate measurements, as demonstrated in a preclinical in vivo study quantifying brain creatine kinase activity.

Funder

Austrian Science Fund

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3