Relative efficiency of precision medicine designs for clinical trials with predictive biomarkers

Author:

Shih Weichung Joe12ORCID,Lin Yong12

Affiliation:

1. Department of Biostatistics, School of Public Health; Rutgers, The State University of New Jersey; 683 Hoes Lane West Piscataway NJ 08854 USA

2. Division of Biometrics, Rutgers Cancer Institute of New Jersey; Rutgers, The State University of New Jersey; 195 Little Albany Street New Brunswick NJ 08901 USA

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference21 articles.

1. Issues in clinical trial designs for tumor marker studies;Sargent;Semin Oncol,2002

2. Randomized clinical trials with biomarkers: design issues;Freidlin;J Natl Cancer Inst,2010

3. Hayes DF A bad tumor marker test is as bad a bad drug: the case for more consistent regulation of cancer diagnostics http://connection.asco.org/blogs

4. Evaluating the efficiency of targeted designs for randomized clinical trials;Simon;Clin Cancer Res,2004

5. On the efficiency of targeted clinical trials;Maitournam;Stat Med,2005

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