Tapering Canakinumab Monotherapy in Patients With Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results From a Phase IIIb/IV Open‐Label, Randomized Study

Author:

Quartier Pierre1ORCID,Alexeeva Ekaterina2,Constantin Tamàs3,Chasnyk Vyacheslav4,Wulffraat Nico5,Palmblad Karin6,Wouters Carine7,I. Brunner Hermine8ORCID,Marzan Katherine9,Schneider Rayfel10,Horneff Gerd11,Martini Alberto12,Anton Jordi13ORCID,Wei Xiaoling14,Slade Alan15,Ruperto Nicolino16ORCID,Abrams Ken15,Emminger W.,Ulbrich A.,Fodor S.,Wouters C.,Desomer L.,Lauwerys B.,Brichard B.,Boulanger C.,Levy G.,Goffin L.,Le P.‐Q.,Bandeira M.,Feitosa Pelajo C.,Knupp Feitosa S.,Costa C.,Felix Rodrigues M.,Almeida da Silva C.,Mattei de L.,Kozu K.,Laxer Ronald,Houghton K.,Tucker L.,Morishita K.,Mogenet A.,Mouy R.,Bader Meunier B.,Meyzer C.,Semeraro M.,Ben‐Brahim O.,Kone‐Paut I.,Galeotti C.,Rossi L.,Dusser P.,Cherquaoui B.,Belot A.,Duquesne A.,Caroline F.,Audrey L.,Desjonqueres M.,Foeldvari I.,Kienast A.,Willig B.,Weissbarth‐Riedel E.,Froehlich A.,Barthel D.,Peitz J.,Wintrich S.,Geikowski T.,Schulz A.,Hufnagel M.,Hirdes M.,Kubicki R.,Kirschner J.,Janda A.,Jacob A.,Emerich C.,Raab A.,Ngoumou G.,Minden K.,Lieber M.,von Stuckrad S.‐L.,Trauzeddel R.,Haselbusch D.,Kolbeck H.,Kuemmerle Deschner J.,Hansmann S.,Schleich T.,Magunia I.,Riethmuller J.,Anders N.,Lehmann H.,de Laffolie J.,Lutz T.,Grulich‐Henn J.,Pfeil J.,Helling‐Bakki A.,Ponyi A.,Garan D.,Orban I.,Sevcic K.,Butbul Y.,Brik R.,Helo M.,Hashkes P.,Toker O.,Haviv R.,Uziel Y.,Haviv R.,Moshe V.,Rothschild M.,Harel L.,Amarilyo G.,Tal R.,Said M.,Tirosh I.,Spielman S.,Gerstein M.,Ravelli A.,Schiappapietra B.,Varnier G.,Finetti M.,Marasini M.,Caorsi R.,Rosina S.,Federici S.,Pontikaki I.,Meroni P.,Gerloni V.,Ughi N.,Ubiali T.,Alessio M.,Della Casa R.,Vastert S.,Swart J.,van Royen‐Kerhof A.,Schatorje E.,Van Iperen‐Schutte G.,Rutkowska‐Sak L.,Szczygielska I.,Kwiatkowska M.,Marusak‐Banacka M.,Gietka P.,Isaeva K.,Denisova R.,Snegireva L.,Dubko M.,Kostik M.,Buchinskaia N.,Kalashnikova O.,Avrusin S.,Masalova V.,Nunez Cuadros E.,Diez G.,Galindo Zavala R.,Bou Torrent R.,Iglesias E.,Calzada J.,Bittermann V.,Boteanu A.,Gamir M. L.,Clemente Garulo D.,Lopez Robledillo J. C.,Merino R.,Alcobendas R.,Remesal A.,Murias S.,Calvo I.,Lopez B.,Gonzalez I.,Fernandez L.,Magnusson Bo,Kasapcopur O.,Barut K.,Adrovic A.,Sahin S.,Erguven M.,Gozdenur Savci R.,Ozen S.,Demir S.,Bilginer Y.,Avci Z. S.,Batu E. D.,Reiff Andreas,Ramanatham Anusha,Brown Diana,Shaham Bracha,Parks Shirley,Cidon Michal,Higgins G.,Spencer C.,Rossette J.,Jones K.,Bout Tabaku S.,Farley S.,Akoghlanian S.,

Affiliation:

1. RAISE Reference Centre for Rare Diseases, Necker–Enfants Malades, AP‐HP, Imagine Institute Paris University Paris France

2. National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation Moscow Russia

3. Semmelweis University Budapest Hungary

4. Saint‐Petersburg State Pediatric Medical University Saint‐Petersburg Russian Federation

5. University Medical Center Utrecht Utrecht The Netherlands

6. Karolinska Institutet Karolinska University Hospital Stockholm Sweden

7. University Hospitals Leuven Leuven Belgium

8. Cincinnati Children’s Hospital Medical Center Cincinnati Ohio United States

9. Children’s Hospital Los Angeles Los Angeles California United States

10. University of Toronto and Hospital for Sick Children Toronto Ontario Canada

11. Asklepios Klinik Sankt Augustin and University Hospital Cologne Sankt Augustin Cologne Germany

12. Istituto Giannina Gaslini IRCCS Genoa Italy

13. Hospital Sant Joan de Déu Esplugues de Llobregat, Spain, and Universitat de Barcelona Barcelona Spain

14. China Novartis Institutes for Biomedical Research, Ltd Beijing China

15. Novartis Pharmaceuticals Corporation East Hanover New Jersey United States

16. Clinica Pediatrica e Reumatologia PRINTO Istituto Giannina Gaslini IRCCS Genoa Italy

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

Reference39 articles.

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