Poor association between dihydropyrimidine dehydrogenase ( <scp> <i>DPYD</i> </scp> ) genotype and fluoropyrimidine‐induced toxicity in an Asian population-Reference-Cited by-同舟云学术

Poor association between dihydropyrimidine dehydrogenase ( DPYD ) genotype and fluoropyrimidine‐induced toxicity in an Asian population

Published:2022-12-16 Issue:7 Volume:12 Page:7808-7814
ISSN:2045-7634
Container-title:Cancer Medicine
language:en
Short-container-title:Cancer Medicine

Author:

Kanai Masashi¹^ORCID,Kawaguchi Takahisa²,Kotaka Masahito³,Manaka Dai⁴,Hasegawa Junichi⁵,Takagane Akinori⁶,Munemoto Yoshinori⁷,Kato Takeshi⁸,Eto Tetsuya⁹,Touyama Tetsuo¹⁰,Matsui Takanori¹¹,Shinozaki Katsunori¹²,Matsumoto Shigemi¹³,Mizushima Tsunekazu¹⁴,Mori Masaki¹⁵,Sakamoto Junichi¹⁶¹⁷,Ohtsu Atsushi¹⁸,Yoshino Takayuki¹⁸,Saji Shigetoyo¹⁶,Matsuda Fumihiko²

Affiliation:

1. Department of Therapeutic Oncology, Graduate School of Medicine Kyoto University Kyoto Japan

2. Center for Genomic Medicine, Graduate School of Medicine Kyoto University Kyoto Japan

3. Gastrointestinal Cancer Center Sano Hospital Kobe Japan

4. Department of Surgery, Gastrointestinal Center Kyoto Katsura Hospital Kyoto Japan

5. Department of Surgery Osaka Rosai Hospital Osaka Japan

6. Department of Surgery Hakodate Goryoukaku Hospital Hakodate Japan

7. Department of Surgery Fukui Ken Saiseikai Hospital Fukui Japan

8. Department of Surgery Kansai Rosai Hospital Amagasaki Japan

9. Department of Gastroenterology Tsuchiura Kyodo General Hospital Ibaraki Japan

10. Department of Surgery Nakagami Hospital Okinawa Japan

11. Department of Gastroenterological Surgery Aichi Cancer Center Aichi Hospital Okazaki Japan

12. Division of Clinical Oncology Hiroshima Prefectural Hospital Hiroshima Japan

13. Department of Real World Data Research and Development Graduate School of Medicine, Kyoto University Kyoto Japan

14. Department of Gastroenterological Surgery Osaka University Graduate School of Medicine Osaka Japan

15. Tokai University School of Medicine Isehara Japan

16. Japanese Foundation for Multidisciplinary Treatment of Cancer Tokyo Japan

17. Tokai Central Hospital Kakamigahara Japan

18. Department of Gastroenterology and Gastrointestinal Oncology National Cancer Center Hospital East Chiba Japan

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.5541

Reference13 articles.

1. Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

2. DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

3. A cost analysis of upfront DPYD genotype–guided dose individualisation in fluoropyrimidine-based anticancer therapy

4. European Medicines Agency.Fluorouracil and fluorouracil related substances Article 31 referral – EMA recommendations on DPD testing prior to treatment with fluorouracil capecitabine tegafur and flucytosine; EMA/367286/2020.

5. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

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1. DPYDgenetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: A systematic review;2023-12-11

2. Personalizing adjuvant therapy for patients with colorectal cancer;Nature Reviews Clinical Oncology;2023-11-24

3. Implementing pharmacogenetic testing in fluoropyrimidine-treated cancer patients: DPYD genotyping to guide chemotherapy dosing in Greece;Frontiers in Pharmacology;2023-09-14

4. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer;ESMO Open;2023-06

5. Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?;Frontiers in Pharmacology;2023-05-15