Author:
Kennington Stuart C. D.,Romea* Pedro,Urpí* Fèlix
Abstract
AbstractThis chapter describes the procedure for synthesis of [(R)‐DTBM‐SEGPHOS]NiCl2for the enantioselective acetal formation fromN‐Propanoyl1,3‐Thiazinane‐2‐thione and trimethyl orthoformate. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards. The procedures in Organic Syntheses are intended for use only by persons with proper training in experimental organic chemistry. The enantioselective and catalytic construction of carbon–carbon bonds from enolates has attracted much attention in recent years.
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