Organocatalytic Dimerization of Succinaldehyde

Abstract

AbstractThis chapter describes the organocatalytic dimerization of succinaldehyde. Mechanistically, the dimerization process proceeds through the formation of an anti‐enamine with succinaldehyde and L‐proline, followed by pseudo‐equatorial approach of a second succinaldehyde to give trialdehyde 5 via transition state 4. The chapter presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. It also describes the hazards associated with working with chemicals and the ways to deal with these hazards.