Preparation of N ‐Formylamides by Oxidative Cleavage of N ‐Acylaminoacids

Abstract

Abstract N ‐Formylamides are versatile intermediates for the preparation of pharmacologically‐preferred 1,2,4‐triazole ring system by the Einhorn‐Brunner reaction. They are also important as starting materials for the rather inaccessible enamide and dienamide functional groups, which are found in several highly biologically‐active natural products. This chapter describes the procedure for preparation of N‐formylamides by oxidative cleavage of N ‐acylaminoacids. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards.