Synthesis of (((1 R ,3 S ,3′ S )‐3,3′‐Diethyl‐3 H ,3′ H ‐1,1′‐spirobi[isobenzofuran]‐7,7′‐diyl)bis(oxy))bis(diphenylphosphane)

Abstract

Abstract This chapter describes the procedure for synthesis of (((1R,3S,3'S)‐3,3'‐Diethyl‐3H,3'H‐1,1'‐spirobi[isobenzofuran]‐7,7'‐diyl)bis(oxy))bis(diphenylphosphane). It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards. Chiral organic ligands have been of great importance for the asymmetric transition‐metal catalysis since the discovery of Noyori asymmetric hydrogenation. After many decades of research, several generally well‐performing privileged ligand scaffolds have been identified.