Visible‐Light‐Promoted C−S Cross‐Coupling Reaction for Synthesis of Aromatic Thioethers

Abstract

Abstract This chapter presents the procedure for the visible‐light‐promoted C–S cross‐coupling reaction for synthesis of aromatic thioethers. Over the last 45 years, numerous procedures have been made for C–S bond formation. The authors investigated and developed a visible‐light‐driven method for C–S bond formation without the use of transition metal catalysts. This synthetic procedure tolerates a broad range of functional groups and a variety of substituted aryl halides can be transformed into the desired products in good yields. Moreover, therapeutics such as indomethacin and fenofibrate can be converted to the corresponding thiolated compounds in good yields. In summary, a practical method for the synthesis of aromatic thioethers is reported. This method features excellent functional group tolerance and good substrate scope.