Large Scale Synthesis of Enantiomerically Pure ( S )‐3‐(4‐Bromophenyl)butanoic Acid

Author:

Ruble J. Craig,Vandeveer H. George,Navarro* Antonio,Palani Vignesh,Sarpong Richmond

Publisher

Wiley

Reference12 articles.

1. Eli Lilly and Company Lilly Research Laboratories Lilly Corporate Center Indianapolis Indiana 46285. Email:navarroa@lilly.com. We thank Lilly Research Laboratories for the use of the laboratories and financial support.

2. Rhodium-Catalyzed Conjugate Addition of Aryl- or 1-Alkenylboronic Acids to Enones

3. The absolute stereochemistry depends on the stereochemistry of the BINAP used as a ligand. Thus (R)‐BINAP gives(S)‐Ethyl 3‐(4‐bromophenyl)butanoateand (S)‐BINAP gives(R)‐Ethyl 3‐(4‐bromophenyl)butanoate.

4. Practical Method for Asymmetric Addition of Arylboronic Acids to α,β-Unsaturated Carbonyl Compounds Utilizing an In Situ Prepared Rhodium Catalyst

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