Potential association between <scp><i>PSCA</i> rs2976395</scp> functional variant and pancreatic cancer risk-Reference-Cited by-同舟云学术

Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk

Published:2024-06-26 Issue:8 Volume:155 Page:1432-1442
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Intl Journal of Cancer

Author:

Corradi Chiara¹^ORCID,Lencioni Giulia¹,Felici Alessio¹^ORCID,Rizzato Cosmeri¹^ORCID,Gentiluomo Manuel¹^ORCID,Ermini Stefano²,Archibugi Livia³⁴,Mickevicius Antanas⁵,Lucchesi Maurizio⁶,Malecka‐Wojciesko Ewa⁷,Basso Daniela⁸,Arcidiacono Paolo Giorgio³,Petrone Maria Chiara³,Carrara Silvia⁹,Götz Mara¹⁰,Bunduc Stefania¹¹¹²¹³¹⁴,Holleczek Bernd¹⁵^ORCID,Aoki Mateus Nóbrega¹⁶,Uzunoglu Faik G.¹⁰,Zanette Dalila Lucíola¹⁶,Mambrini Andrea⁶,Jamroziak Krzysztof¹⁷,Oliverius Martin¹⁸,Lovecek Martin¹⁹,Cavestro Giulia Martina²⁰,Milanetto Anna Caterina²¹,Peduzzi Giulia¹,Duchonova Beatrice Mohelnikova²²,Izbicki Jakob R.¹⁰,Zalinkevicius Rimantas²³,Hlavac Viktor²⁴,van Eijck Casper H. J.²⁵,Brenner Hermann²⁶²⁷²⁸,Vanella Giuseppe³⁴,Vokacova Klara²⁹³⁰,Soucek Pavel²⁴,Tavano Francesca³¹^ORCID,Perri Francesco³¹,Capurso Gabriele³⁴,Hussein Tamás¹³¹⁴,Kiudelis Mindaugas⁵,Kupcinskas Juozas³²,Busch Olivier R.³³,Morelli Luca³⁴,Theodoropoulos George E.³⁵,Testoni Sabrina Gloria Giulia³,Adamonis Kestutis³²³³,Neoptolemos John P.³⁵,Gazouli Maria³⁶^ORCID,Pasquali Claudio²¹,Kormos Zita¹⁴,Skalicky Pavel¹⁹,Pezzilli Raffaele³⁷,Sperti Cosimo²¹,Kauffmann Emanuele³⁸,Büchler Markus W.³⁹,Schöttker Ben²⁶,Hegyi Péter¹³¹⁴⁴⁰⁴¹,Capretti Giovanni⁴²⁴³,Lawlor Rita T.⁴⁴,Canzian Federico⁴⁵^ORCID,Campa Daniele¹^ORCID

Affiliation:

1. Department of Biology University of Pisa Pisa Italy

2. Blood Transfusion Service Azienda Ospedaliera‐Universitaria Meyer, Children's Hospital Florence Italy

3. Pancreato‐Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center IRSSC San Raffaele Scientific Institute Milan Italy

4. Digestive and Liver Disease Unit Sant'Andrea Hospital Rome Italy

5. Department of Surgery Lithuanian University of Health Sciences Kaunas Lithuania

6. Oncology of Massa Carrara, Oncological Department Azienda USL Toscana Nord Ovest Carrara Italy

7. Department of Digestive Tract Diseases Medical University of Lodz Lodz Poland

8. Laboratory Medicine, Department DIMED University of Padova Padua Italy

9. Endoscoopic Unit, Gastroenterology Department IRCCS Humanitas Research Hospital Rozzano, Milan Italy

10. Department of General, Visceral and Thoracic Surgery University Hospital Hamburg‐Eppendorf Hamburg Germany

11. Carol Davila University of Medicine and Pharmacy Bucharest Romania

12. Digestive Diseases and Liver Transplantation Center Fundeni Clinical Institute Bucharest Romania

13. Center for Translational Medicine Semmelweis University Budapest Hungary

14. Division of Pancreatic Diseases, Heart and Vascular Center Semmelweis University Budapest Hungary

15. Saarland Cancer Registry Saarbrücken Germany

16. Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute Oswaldo Cruz Foundation (Fiocruz) Curitiba Parana Brazil

17. Department of Hematology, Transplantation and Internal Medicine Medical University of Warsaw Warsaw Poland

18. Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine Charles University Prague Czech Republic

19. University Hospital Olomouc Olomouc Czech Republic

20. Gastroenterology and Gastrointestinal Endoscopy Unit, Vita‐Salute San Raffaele University IRCCS San Raffaele Scientific Institute Milan Italy

21. Department of DiSCOG University of Padova Padua Italy

22. Faculty of Medicine and Dentistry Palacky University Olomouc Olomouc Czech Republic

23. Clinics of Institute of Endocrinology Lithuanian University of Health Sciences Kaunas Lithuania

24. Faculty of Medicine in Pilsen, Biomedical Center Charles University Pilsen Czech Republic

25. Department of Surgery Erasmus MC University Medical Center Rotterdam The Netherlands

26. Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany

27. Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg Germany

28. German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany

29. Department of Molecular Biology of Cancer Institute of Experimental Medicine of the Czech Academy of Sciences Prague Czech Republic

30. Institute of Biology and Medical Genetics, First Faculty of Medicine Charles University Prague Czech Republic

31. Division of Gastroenterology and Research Laboratory Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital San Giovanni Rotondo Italy

32. Gastroenterology Department, Institute for Digestive Research Lithuanian University of Health Sciences Kaunas Lithuania

33. Department of Surgery, Amsterdam UMC University of Amsterdam, Cancer Center Amsterdam Amsterdam The Netherlands

34. General Surgery, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa Italy

35. First Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School National and Kapodistrian University of Athens Athens Greece

36. Department of Basic Medical Sciences, Laboratory of Biology, Medical School National and Kapodistrian University of Athens Athens Greece

37. Potenza County Medical Association Potenza Italy

38. Division of General and Transplant Surgery Pisa University Hospital Pisa Italy

39. Department of General Surgery University of Heidelberg Heidelberg Germany

40. Institute for Translational Medicine, Medical School University of Pécs Pécs Hungary

41. János Szentágothai Research Center University of Pécs Pécs Hungary

42. Pancreatic Surgery Department IRCCS Humanitas Research Hospital Rozzano, Milan Italy

43. Humanitas University Rozzano, Milan Italy

44. ARC‐NET Centre for Applied Research on Cancer University and Hospital Trust of Verona Verona Italy

45. Genomic Epidemiology Group German Cancer Research Center (DKFZ) Heidelberg Germany

Abstract

AbstractCorrelated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single‐nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV‐SNPs and 133,615 CoRSIV‐mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10−5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan‐meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer; however, functional studies are needed to elucidate the function relevance of the association.

Funder

Fondazione Arpa

Deutsches Krebsforschungszentrum

Ministero della Salute

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.35046

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