Efficacy and Safety of <scp>ABBV</scp> ‐3373, a Novel Anti–Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody–Drug Conjugate, in Adults with <scp>Moderate‐to‐Severe</scp> Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, <scp>Double‐Blind</scp> , <scp>Active‐Controlled Proof‐of‐Concept</scp> Phase <scp>IIa</scp> Trial-Reference-Cited by-同舟云学术

Efficacy and Safety of ABBV ‐3373, a Novel Anti–Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody–Drug Conjugate, in Adults with Moderate‐to‐Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double‐Blind , Active‐Controlled Proof‐of‐Concept Phase IIa Trial

Published:2023-04-02 Issue: Volume: Page:
ISSN:2326-5191
Container-title:Arthritis & Rheumatology
language:en
Short-container-title:Arthritis & Rheumatology

Author:

Buttgereit Frank¹^ORCID,Aelion Jacob²,Rojkovich Bernadette³,Zubrzycka‐Sienkiewicz Anna⁴,Chen Su⁵,Yang Yang⁵,Arikan Dilek⁵,D'Cunha Ronilda⁵,Pang Yinuo⁵,Kupper Hartmut⁶,Radstake Timothy⁵,Amital Howard⁷

Affiliation:

1. Department of Rheumatology and Clinical Immunology Charité University Medicine, and Clinical Immunology Berlin Germany

2. West Tennessee Research Institute Jackson Tennessee

3. Polyclicic of the Hospitaller Brothers of St. John of God in Budapest Budapest Hungary

4. Reumatika–Centrum Reumatologii, ARS Rheumatica sp.z.o.o Warsaw Poland

5. AbbVie Inc. North Chicago Illinois

6. AbbVie Deutschland GmbH & Co. KG, Ludwigshafen Germany

7. Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases Medical Center, Department of Medicine ‘B’, Tel‐Hashomer, Israel, and the Sheba Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel

Funder

AbbVie

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.42415

Reference27 articles.

1. Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

2. Novel treatment strategies in rheumatoid arthritis

3. Pathogenetic insights from the treatment of rheumatoid arthritis