Novel Pirinixic Acids as PPARα Preferential Dual PPARα/γ Agonists-Reference-Cited by-同舟云学术

Novel Pirinixic Acids as PPARα Preferential Dual PPARα/γ Agonists

Published:2009-05 Issue:5 Volume:28 Page:576-586
ISSN:1611-020X
Container-title:QSAR & Combinatorial Science
language:en
Short-container-title:QSAR Comb. Sci.

Author:

Zettl Heiko,Dittrich Michaela,Steri Ramona,Proschak Ewgenij,Rau Oliver,Steinhilber Dieter,Schneider Gisbert,Lämmerhofer Michael,Schubert-Zsilavecz Manfred

Publisher

Wiley

Subject

Organic Chemistry,Computer Science Applications,Drug Discovery

Reference20 articles.

1. Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy

2. Roles of PPARs in health and disease

3. The PPARs: From Orphan Receptors to Drug Discovery

4. The Treatment of Dyslipidemia—What's Left in the Pipeline?

5. PPARs: therapeutic targets for metabolic disease

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1. Pirinixic acids: flexible fatty acid mimetics with various biological activities;Future Medicinal Chemistry;2015-08

2. Molecular determinants for improved activity at PPARα: Structure–activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα;Bioorganic & Medicinal Chemistry Letters;2014-08

3. Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition;Bioorganic & Medicinal Chemistry Letters;2014-08

4. Aminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E2 Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo;Journal of Medicinal Chemistry;2013-11-15

5. Tertiary Alkylamines as Nucleophiles in Substitution Reactions at Heteroaromatic Halide During the Synthesis of the Highly Potent Pirinixic Acid Derivative 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic Acid (YS-121);Molecules;2011-12-05