Tobacco Cessation Following Laryngeal Cancer Diagnosis Predicts Response to Treatment and Laryngectomy‐Free Survival

Author:

Krutz Matthew1,Acharya Pawan2,Elliott Jacey1,Zhao Daniel23,Mhawej Rachad1,Queimado Lurdes1345ORCID

Affiliation:

1. Department of Otolaryngology–Head and Neck Surgery The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

2. Department of Biostatistics and Epidemiology The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

3. Stephenson Cancer Center The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

4. Department of Cell Biology The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

5. TSET Health Promotion Research Center, Stephenson Cancer Center The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

Abstract

AbstractObjectiveTo determine the effect of tobacco cessation following laryngeal cancer diagnosis on response to first‐line therapy, laryngectomy‐free survival, and overall survival in patients who were current smokers at the time of diagnosis.Study DesignRetrospective, case‐control study.SettingOU Stephenson Cancer Center, National Cancer Institute‐Designated Cancer Center.MethodsWe included 140 patients diagnosed with laryngeal squamous cell carcinoma, who were current smokers at the time of diagnosis, and were treated with first‐line definitive radiation or chemo/radiation with the intent to cure. The association between patient characteristics and treatment response was assessed using the χ2 test and logistic regression analysis. Survival outcomes were analyzed using Kaplan‐Meier methods and Cox proportional‐hazards models.ResultsOf the 140 current smokers, 61 patients (45%) quit smoking prior to treatment initiation. In adjusted logistic regression analysis, quitters had 3.7 times higher odds of achieving a complete response to first‐line therapy than active smokers (odds ratio: 3.694 [1.575‐8.661]; P = .003). In the adjusted Cox proportional‐hazards model, quitters were 54% less likely to require salvage laryngectomy within 7 years of diagnosis than active smokers (hazard ratio: 0.456 [0.246‐0.848]; P = .013). Quitters had a statistically significant increase in 7‐year overall survival compared to active smokers (P = .02).ConclusionThis is the first study to show that in newly diagnosed laryngeal cancer patients who are current smokers at the time of diagnosis, tobacco cessation significantly increases therapy response, laryngectomy‐free survival, and overall survival. These data stress the importance of systematically incorporating tobacco cessation programs into laryngeal cancer treatment plans.

Publisher

Wiley

Subject

Otorhinolaryngology,Surgery

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3