Current Perspectives of Limbal-Derived Stem Cells and its Application in Ocular Surface Regeneration and Limbal Stem Cell Transplantation

Author:

Singh Vivek1ORCID,Tiwari Anil23,Kethiri Abhinav Reddy1,Sangwan Virender Singh3ORCID

Affiliation:

1. Stem Cell Biology Laboratory  Center for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, India

2. Department of Ophthalmology  University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. Department of Cornea and Uveitis  Dr. Shroff's Charity Eye Hospital, New Delhi, India

Abstract

Abstract Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.

Funder

Indian Council of Medical Research

SERB

Hyderabad Eye Research Foundation and Science and Engineering Research Board (SERB), India

Science and Engineering Research Board

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,General Medicine

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