Time to reconsider antibiotic prophylaxis in women with prolonged rupture of membranes: The trend of Enterobacteriaceae in peripartum infections

Abstract

AbstractObjectiveThe proportion of neonatal early‐onset sepsis (EOS) by gram‐negative bacteria has increased. The authors examined bacterial distribution in the amniotic membrane cultures of women with peripartum fever (PPF) and related perinatal outcomes.MethodsThis retrospective study covered the period 2011 to 2019. The primary outcomes were Enterobacteriaceae‐positive birth culture rates in women with PPF and the trend of ampicillin resistance. Maternal and neonatal outcomes were compared between women with group B Streptococcus (GBS) and Enterobacteriaceae‐positive isolates. Bacterial distribution was also compared according to rupture of membrane (ROM) duration.ResultsAmong 621 women with PPF, the positive birth culture rate was 52%. Increasing prevalences of ampicillin‐resistant Enterobacteriaceae (81%) were noted. Positive birth cultures were associated with maternal bacteremia (P = 0.017) and neonatal EOS (P = 0.003). Prolonged ROM ≥18 h was associated with increased risk for Enterobacteriaceae‐positive cultures, while intrapartum ampicillin and gentamicin were associated with lower risk. Enterobacteriaceae‐positive compared with GBS‐positive birth cultures were associated with adverse maternal and neonatal outcomes.ConclusionPositive birth cultures were related to maternal bacteremia and neonatal sepsis. Adverse outcomes were more prevalent among women with Enterobacteriaceae‐positive versus GBS‐positive birth cultures. Prolonged ROM is a risk factor for Enterobacteriaceae‐positive birth cultures among women with PPF. Antibiotic prophylaxis treatment for prolonged ROM should be reconsidered.