Thermal‐Induced Synthesis of Cyclobute[b]indolines via Intramolecular Formal [2+2] Cycloaddition of Enamines and Triazole‐derived Ketenimines

Abstract

AbstractA de novo synthesis of cyclobutene‐fused indoline derivatives via thermally induced intramolecular cyclization was reported. This approach efficiently yields valuable high‐strained cyclobute[b]indolines in moderate to high yields and enables further transformation into other valuable heterocycles, demonstrating its potential in organic synthesis.