Catalyst‐Controlled Divergent C3/C5 Site‐Selective C−H Arylation of 2‐Pyridylthiophenes-Reference-Cited by-同舟云学术

Catalyst‐Controlled Divergent C3/C5 Site‐Selective C−H Arylation of 2‐Pyridylthiophenes

Published:2023-09-27 Issue:21 Volume:365 Page:3674-3679
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Huang Xuecong¹,Zhou Pengfei¹,Yang Xingdong¹,Wang Ruiyi¹,Huang Guan¹,Liang Taoyuan¹²³^ORCID,Zhang Zhuan¹²³^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering Guangxi University Nanning 530004 People's Republic of China

2. Guangxi Key Laboratory of Electrochemical Energy Materials Guangxi University Nanning Guangxi 530004 People's Republic of China

3. Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development Guangxi University Nanning Guangxi 530004 People's Republic of China

Abstract

AbstractThe development of a rational protocol to realize the complete regioselectivity and the capability to switch regioselectivity is an appealing yet challenging task. Herein, a regiodivergent C−H arylation of 2‐pyridylthiophenes has been demonstrated via the choice of RuII and PdII catalysts. The reactions proceeded smoothly in a good regioselective manner to afford the corresponding C3‐ and C5‐arylated thiophenes. Late‐stage diversification of biologically relevant scaffold derived from estrone and successful transformation of the products further highlighted the potential utility and importance of this synthetic strategy.

Funder

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202300724

Reference80 articles.

2. Cancer Chemotherapy and Heterocyclic Compounds

3. FORMULATION AND IN-VITRO EVALUATION OF TRANSDERMAL FILMS OF AN ANTI HYPERTENSIVE DRUG

4. A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Regiodivergent C–H Arylation of Thiophenes;Synfacts;2023-11-15