Affiliation:
1. Department of Chemistry and Biochemistry School of Advanced Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo 169-8555 Japan
Abstract
AbstractA mechanism‐navigated enantioselective alkylation of an indole C2 C−H bond with an internal alkene was developed. Under the unconventional ligand‐to‐metal catalyst ratio, a moderate enantiomeric ratio (er), ranging from 70:30 to 88:12, was achieved with our original ligand. We propose that chain‐walking and bond formation are mechanistically independent and suggest that hydridoiridium generated from the C−H source does not play a role in the chain‐walking process.
Funder
Nagase Science Technology Foundation
Waseda University
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