Affiliation:
1. College of Chemistry and Institute of Green Catalysis Zhengzhou University No. 100, Science Road Zhengzhou City Henan Province 450000 People's Republic of China
Abstract
AbstractThis report has realized the catalytic asymmetric [3+2] annulation of benzylideneindolinones with CF3‐containing isatin‐derived azomethine ylides for the first time, in which the organocatalysis has failed. In the presence of dinuclear zinc catalysts, a series of functionalized 2,3‐pyrrolidinyl dispirooxindoles have been synthesized in good yields with excellent stereoselectivity under mild reaction conditions. This protocol can be run on a gram scale and a possible catalytic mechanism is proposed.
Subject
Organic Chemistry,Catalysis