Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase-Reference-Cited by-同舟云学术

Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase

Published:2024-07-23 Issue:15 Volume:366 Page:3290-3296
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

De Marchi Elisa¹,Hilberath Thomas²,Zippilli Claudio¹,Wever Ron³,Saladino Raffaele¹^ORCID,Hollmann Frank²^ORCID,Botta Lorenzo¹

Affiliation:

1. Department of Biological and Ecological Sciences University of Viterbo Via S.C. De Lellis s.n.c. 01100 Viterbo Italy

2. Department of Biotechnology Delft University of Technology Delft 2629HZ The Netherlands

3. van'tHoff Institute for Molecular Sciences University of Amsterdam Amsterdam 1098 XH The Netherlands

Abstract

AbstractVicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi‐enzymatic sequence that allows to obtain vic‐halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method

Funder

European Commission

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202400516

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