Affiliation:
1. Medicinal and Process Chemistry Division CSIR-Central Drug Research Institute Lucknow 226031 India
2. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India
Abstract
AbstractEasy access to divergent products with chemoselectivity is of great importance in organic synthesis. Herein, we have developed a chemoselective copper‐catalyzed carbene insertion protocol onto N−H bonds of tryptamine derivatives. Divergent insertion products are obtained by varying the nucleophilicity of the aliphatic NH of tryptamine with electron‐donating or electron‐withdrawing groups. The reaction provided N−H insertion products with broad substrate scope in good yields.
Funder
Science and Engineering Research Board
Cited by
1 articles.
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