Affiliation:
1. Key Laboratory of Optic-electric Sensing and Analytic Chemistry for Life Science MOE College of Chemistry and Molecular Engineering Qingdao University of Science & Technology Qingdao 266042 People's Republic of China
Abstract
AbstractA palladium‐catalyzed [4+4] cycloaddition of aryl‐substituted γ‐methylidene‐δ‐valerolactones (GMDVs) with divinylketones (DVKs) was developed, providing an approach to access various mono‐cyclic tetrahydro‐2H‐oxocines with diverse substituents in 41% to 95% yield with 81:19 to >20:1 dr. This reaction was facilitated by anchoring olefin (C=C), carbonyl (C=O), and arene (Ar) at the α‐position of carbonyls.
Funder
National Natural Science Foundation of China