Affiliation:
1. College of Pharmacy Zhejiang University of technology Hangzhou Zhejiang 310014 People's Republic of China
2. College of Pharmacy Qiqihar Medical University Qiqihar Heilongjiang 161006 People's Republic of China
3. Zhejiang Hisoar Pharmaceutical Co., Ltd. Taizhou 318000 People's Republic of China
Abstract
AbstractHerein, an eco‐friendly and atom‐economical electrochemical methodology with isatins and 1,2,3,4‐tetrahydroisoquinolines through NHPI/O2‐mediated intermolecular oxidation/annulation is disclosed, leading to a variety of polycyclic quinazolinones in 46–82% yields. This oxidative cyclization proceeded in transition metal‐ and strong oxidant‐free conditions and generated H2 and CO2 as byproducts. Additionally, late‐stage functionalization and broad substrate scope demonstrated the synthetic usefulness of this protocol.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
China Postdoctoral Science Foundation