Affiliation:
1. Guangdong Provincial Key Laboratory of Chiral Molecules and Drug Discovery School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 People's Republic of China
2. Instrumental Analysis & Research Center Sun Yat-sen University Guangzhou 510275 People's Republic of China
Abstract
AbstractAn operationally simple anhydrous carbene insertion reaction to construct DNA‐encoded libraries (DEL) is reported. The developed reaction employs visible light photolysis of diazo compounds and Reversible Adsorption to Solid Support (RASS) strategy. From readily available amines, alcohols, phenols, and carboxylic acids, a variety of high‐value molecules, including useful unnatural amino acids, ethers, and esters, promising clinical drug derivatives, and bioactive molecules have been constructed.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Guangdong Provincial Key Laboratory of Construction Foundation
Cited by
3 articles.
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