Affiliation:
1. Key Laboratory of Geriatric Nutrition and Health Ministry of Education; Beijing Key Laboratory of Flavor Chemistry Beijing Technology and Business University Beijing 100048 People's Republic of China
Abstract
AbstractThe α‐hydroxy‐β‐dicarbonyl motif is essential in many biologically active compounds, sparking significant interest in their synthesis. This review comprehensively examines the advancements in the α‐hydroxylation of β‐dicarbonyl compounds, systematically categorizing the methods based on the types of oxidants employed and highlighting advances in asymmetric α‐hydroxylation. It evaluates the substrate scope, advantages, and disadvantages of each approach, summarizing the possible intermediates involved and the types of reaction mechanisms.
Funder
National Natural Science Foundation of China