Affiliation:
1. College of Chemistry and Chemical Engineering State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha 410082 People's Republic of China
Abstract
AbstractHerein, we present a method for electrochemical‐induced 1,3‐oxohydroxylation of arylcyclopropanes with H2O as the green oxygen source. This transformation offers a regioselective route to highly functionalized β‐hydroxy ketones under oxidant‐ and metal‐free conditions. Notably, this electrochemical approach features simple operation, good regioselectivity, high functional group tolerance, and easy derivatization of the products. Mechanistic studies have provided solid evidences that 1,3‐diol acts as the crucial intermediate in this reaction, leading to the observed regioselectivity.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province