DABCO‐Catalysed [3+2] Cyclization/Deformylation Cascade of <i>p</i>‐Quinols with 3‐Formylchromones: Access to Benzopyrone‐Fused Tetracyclic Ring Systems-Reference-Cited by-同舟云学术

DABCO‐Catalysed [3+2] Cyclization/Deformylation Cascade of p‐Quinols with 3‐Formylchromones: Access to Benzopyrone‐Fused Tetracyclic Ring Systems

Published:2023-02-17 Issue:5 Volume:365 Page:715-721
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Liu Xiong‐Wei¹,Lin Xiao‐Tong²,Zhao Cheng²,Hu Xiao‐Wei²,Xu Yi‐Bing²,Zheng Yi‐Lin²,Liu Xin‐Ni²,Chen Guo‐Shu²,Chen Long³^ORCID,Liu Yun‐Lin²³^ORCID

Affiliation:

1. School of Pharmacy Guizhou University of Traditional Chinese Medicine Guiyang 550025 People's Republic of China

2. School of Chemistry and Chemical Engineering Guangzhou University 230 Wai Huan Xi Road Guangzhou 510006 People's Republic of China

3. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of Antibiotics School of Pharmacy Chengdu University Chengdu 610106 People's Republic of China

Abstract

AbstractThe construction of benzopyrone‐fused hydrobenzofuranones via DABCO‐catalyzed [3+2] cyclization/deformylation cascade of p‐quinols with 3‐formylchromones is described. The reaction works under mild reaction conditions to provide the desired products in 53–90% yields with complete diastereoselectivities. In addition, an enantioselective version with 81% ee is also realized in the presence of Takemoto's chiral thiourea catalyst.

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Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Natural Science Foundation of Sichuan Province

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202201310

Reference77 articles.