Mg(II)‐Catalyzed [4+2] Annulation for the Synthesis of 2‐Arylquinoline Motifs: Applications and DFT Studies

Abstract

Mg‐catalyzed [4+2] cycloaddition reactions between 2‐aminobenzaldehydes and ynones offered an array of 2‐arylquinoline motifs merged with a CF3‐acyl group. Furthermore, with Mg‐catalyzed [4+2] annulation as the key step, DDD107498, DDD102542, and Hit analogues were assembled. Finally, a computational study of the reaction mechanism was conducted.