Synthesis of Acyl Fluorides from Carboxylic Acids with KI/AgSCF3 for Efficient Amide and Peptide Synthesis

Abstract

AbstractA facile synthesis of acyl fluorides from carboxylic acids in a practical and byproduct‐free manner was effected with commercially available KI/AgSCF3 reagents under conditions of high functional group tolerance, and the acyl fluoride intermediates were easily transformed to the corresponding esters, amides, and several carbon‐carbon bond‐forming products. This approach can be successfully applied to straightforward peptide synthesis from amino acids including sterically hindered amino acids.magnified image