Affiliation:
1. Departament de Química and Centro de Innovación en Química Avanzada (ORFEO-CINQA) Universitat Autònoma de Barcelona 08193 Bellaterra Spain
Abstract
AbstractA photochemical synthesis of biologically relevant benzyl oxindoles is presented via electron‐donor acceptor (EDA) complex strategy. This exogenous photocatalyst‐free method describes the formation of a new electron donor‐acceptor complex based on potassium carbonate and thianthrenium salts for C(sp2)−C(sp3) bond formation. This transition‐metal free reaction allows a rapid increase in oxindoles molecular complexity chemical space, tolerating different functional groups as well as sophisticated biomolecules. The scalability and sustainability of this method is highlighted by an important waste recovery protocol. Mechanistic investigations support the formation of an EDA complex that induces a radical chain, and the applicability of this method is showcased by straightforward derivatization reactions.
Cited by
3 articles.
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