Affiliation:
1. School of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D Guizhou Medical University 550014 Guiyang P. R. China
2. Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University 550004 Guiyang P. R. China.
Abstract
AbstractHerein, the use of triphenylmethylium tetrakis(pentafluorophenyl)borate as an efficient catalyst for the intermolecular dehydrative coupling of p‐hydroxymandelic acid hydrate with substituted aromatic amines and (thio)phenols was developed, which allows for the preparation of arylacetic acid derivatives in a convenient manner. Notably, this method offers several advantages, including being prefunctionalization free, high atom efficiency, and high regioselectivity. Additionally, it exhibits a broad substrate scope, enabling the synthesis of a range of arylacetic acid derivatives. Furthermore, this method can also be applied to the etherification of arylthiol derivatives, facilitating the preparation of various thiolated products, which would enhance the applicability and potential utility of this method in organic synthesis.
Funder
National Natural Science Foundation of China
Guizhou Medical University
Department of Education of Guizhou Province