Oxidative Alkenylation of (Hetero)aromatics with Unactivated Alkenes: Control of the Reaction Selectivity

Author:

Hu Chenhui1,Xiang Keyu1ORCID,Ying Tao1,Yu Jingbo1ORCID

Affiliation:

1. Laboratory of Pharmaceutical Engineering of Zhejiang Province Key Laboratory for Green Pharmaceutical Technologies Related Equipment of Ministry of Education Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals. Zhejiang University of Technology Hangzhou 310014 People's Republic of China

Abstract

AbstractAlkenylbenzene skeletons represent one of the most widely occurring structural motifs in pharmaceutical drugs, natural products, and advanced materials. The construction of alkenylbenzenes is promising through the use of a straightforward oxidative alkenylation protocol, particularly from unactivated alkenes. This is significant because unactivated alkenes are inexpensive raw materials that can be obtained in bulk quantities from petrochemical feedstocks and renewable resources. However, controlling the reactivity and regioselectivity of olefination with unbiased olefins remains a significant challenge, necessitating continuous efforts and potentially having a substantial impact on both organic synthesis and the industry. This review aims to provide an overview of the latest advances in regiocontrol strategies for oxidative alkenylation reactions with unactivated alkenes, which can be categorized into three types: 1) ligand‐promoted/accelerated reactions; 2) prefunctionalized olefins‐facilitated reactions; 3) directing group‐induced reactions.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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