Affiliation:
1. National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province College of Chemistry and Chemical Engineering Hunan Normal University Changsha 410081 People's Republic of China
Abstract
AbstractHerein a Pd(II)‐catalyzed C−H silylation of o‐alkynylanilines with hexamethyldisilane for the synthesis of disilylated 2‐phenyl‐1H‐indoles is reported. In this reaction, o‐alkynylanilines undergo an aminopalladation, C−H activation, and dealkylation sequence to form five‐membered C,C‐palladacycles, which then couple with hexamethyldisilane to construct one C−N bond and two C−Si bonds. This method provides an alternative strategy for C−H silylation.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province