Affiliation:
1. State Key Lab of Urban Water Resource and Environment School of Science Harbin Institute of Technology (Shenzhen) Shenzhen 518055 People's Republic of China
2. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang Henan 453007 People's Republic of China
Abstract
AbstractAn electrochemical Reformatsky‐type reaction of bromodifluoroamides with aldehydes/ketones via electron reductive umpolung is reported, leading to the generation of a series of β‐hydroxy‐α,α‐difluoro amides in moderate to good yields. This protocol tolerated a variety of commercially available alkyl ketone, alkyl and aromatic aldehydes, featuring broad substrate scope and good functional group tolerance under transition metal‐free conditions without metal reduction reagents. Control experiment indicated that the reaction proceeded via an electron reductive umpolung pathway.
Funder
Shenzhen Graduate School, Peking University
Natural Science Foundation of Guangdong Province
Basic and Applied Basic Research Foundation of Guangdong Province