Affiliation:
1. Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and Function CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences (CAS) Beijing 100190 People's Republic of China
2. University of Chinese Academy of Sciences Beijing 100049 People's Republic of China
Abstract
AbstractBoth furan and 1,4‐dihydropyridine (1,4‐DHP) are key structural motifs in pharmaceuticals. Herein, we report the synthesis of 4‐(furan‐2‐ylmethyl)‐1,4‐dihydropyridines from pyridiniums and furfural derivatives under NHC catalysis. This reaction involves the generation of NHC‐bounded trienolates from furfural derivatives and following addition to the C‐4 position of N‐aryl pyridinium salts. This protocol features good yields (41–99%), and high levels of regioselectivity (>20:1 for all cases).
Funder
National Natural Science Foundation of China
Beijing National Laboratory for Molecular Sciences
Cited by
1 articles.
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