A Class of Chiral‐Bridged Biphenyl Monophosphine Ligands with Benzofuran Moiety and The Application in Diastereo‐ and Enantioselective Au(I)‐Catalyzed Cycloaddition-Reference-Cited by-同舟云学术

A Class of Chiral‐Bridged Biphenyl Monophosphine Ligands with Benzofuran Moiety and The Application in Diastereo‐ and Enantioselective Au(I)‐Catalyzed Cycloaddition

Published:2024-07 Issue:14 Volume:366 Page:3105-3110
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

He Xiaobo¹,Pan Bendu¹,Zhang Yaqi¹^ORCID,Chen Bin¹,Jiang Long²,Qiu Liqin¹^ORCID

Affiliation:

1. School of Chemistry, IGCME Guangdong Provincial Key Laboratory of Chiral Molecules and Drug Discovery The Key Laboratory of Low-Carbon Chemistry & Energy Conservation of Guangdong Province Sun Yat-sen University Guangzhou 510006 People's Republic of China

2. Instrumental Analysis and Research Centre Sun Yat-sen University Guangzhou 510275 People's Republic of China

Abstract

AbstractA class of novel chiral‐bridged biphenyl monophosphine ligands with a benzofuran moiety (He‐phos) has been successfully synthesized and reported. These ligands exhibited good performance in the gold‐catalyzed enantioselective cycloaddition reaction of 2‐(1‐alkynyl)‐2‐en‐1‐ones with nitrones, resulting in the successful preparation of a series of polyaryl‐substituted heterocyclic compounds with high enantioselectivities (up to 99% yield, 98% ee). The wide substrate adaptability (53 examples) and mild reaction conditions demonstrate the practicability of He‐phos in this reaction.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202400433

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