Metal‐Free Oxidative [5+1] Cyclization of 1,5‐Enynes for the Synthesis of Pyrazine 1‐Oxide-Reference-Cited by-同舟云学术

Metal‐Free Oxidative [5+1] Cyclization of 1,5‐Enynes for the Synthesis of Pyrazine 1‐Oxide

Published:2020-07-31 Issue:17 Volume:362 Page:3621-3626
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv. Synth. Catal.

Author:

Xia Xiao‐Feng¹,Zhao Mingming¹,He Wei¹,Zou Lianghua²,San Xinxin¹,Wang Dawei¹

Affiliation:

1. Key Laboratory of Synthetic and Biological ColloidsMinistry of EducationSchool of Chemical and Material EngineeringJiangnan University Wuxi Jiangsu 214122 People's Republic of China

2. School of Pharmaceutical SciencesJiangnan University Wuxi Jiangsu 214122 People's Republic of China.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202000756

Reference73 articles.

2. 6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

3. Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

4. Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

5. Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

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